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Why Some Old People Act Half Their Age: It’s in the Brain

Scientists are studying people over 80 whose memories are just as good as someone in their 50s. What sets these ‘SuperAgers’ apart?

Is the Internet Changing Our Memory? – https://youtu.be/InlMjKJBrbE
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Umbilical Cord Plasma Could Help Preserve Memory in Aging Populations
https://www.seeker.com/health/medicine/umbilical-cord-plasma-could-help-preserve-memory-in-aging-populations
“A protein found in high levels in umbilical cord plasma may hold a secret to improving memory and mental activity among aging populations, according to new research. A team of neuroscientists at Stanford University found that injecting old mice with human umbilical cord plasma significantly improved their memory and testing performance.”

Life-Extending Discovery Renews Debate Over Aging as a ‘Disease’
https://www.seeker.com/health/biotech/life-extending-discovery-renews-debate-over-aging-as-a-disease
“David Sinclair has been reverse-engineering the aging process for two decades. As the co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, Sinclair and his colleagues have identified several key enzymes and interactions inside cells that cause them to “lose their identity” over time, making our bodies more susceptible to diseases like cancer, heart disease, and dementia. But what if aging itself is the real disease?”

Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity
http://www.jneurosci.org/content/35/4/1781
“This human study is based on an established cohort of “SuperAgers,” 80+-year-old individuals with episodic memory function at a level equal to, or better than, individuals 20-30 years younger. A preliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds. Here, we investigated the in vivo structural features of cingulate cortex in a larger sample of SuperAgers and conducted a histologic analysis of this region in postmortem specimens.”

The Influence of Exercise on Cognitive Abilities
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951958/
“Scientific evidence based on neuroimaging approaches over the last decade has demonstrated the efficacy of physical activity improving cognitive health across the human lifespan. Aerobic fitness spares age-related loss of brain tissue during aging, and enhances functional aspects of higher order regions involved in the control of cognition.”

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Special thanks to Sapna Parikh for hosting and writing this episode of Seeker!
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