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The Accidental Discovery of LSD: The Story of Bicycle Day

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Bicycle day’s just around the corner, but it’s not what you think. This isn’t a holiday honoring your favorite two wheeled, environmentally friend vehicle – it’s about the day chemist Albert Hoffman first discovered the psychedelic effects of Lysergic Acid Diethylamide, or LSD-25. Today we’re talking the chemical history of LSD, so get ready to turn on, tune in, but don’t drop out… you might just learn something.

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Writer & Producer:
Kirk Zamieroski

Executive Producer:
Adam Dylewski

Scientific consultants:
Sonja Krane, Ph.D.
Darcy Gentleman, Ph.D.
Kyle Nackers

Music:
Pure Natural – Touch Me
Robert Daglio – Com Todo Meu Amor

SOURCES:

On Ergot – http://www.rcpe.ac.uk/journal/issue/journal_39_2/lee.pdf

Ergot Abortions – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2558386/?page=1

Headache remedy –
http://www.nytimes.com/health/guides/disease/migraine/medications-for-treating-migraine-attacks.html

Ergotamine – https://www.ncbi.nlm.nih.gov/pubmed/12383066

Total Synthesis of Lysergic Acid – http://pubs.acs.org/doi/pdf/10.1021/ja01594a039

LSD: My Problem Child – http://www.maps.org/images/pdf/books/lsdmyproblemchild.pdf

Article on LSD Discovery – https://www.theatlantic.com/health/archive/2014/09/the-accidental-discovery-of-lsd/379564/

Mystirc Chemist: The life of Albert Hofman – http://www.synergeticpress.com/wp-content/uploads/2013/04/MYSTICCHEMISTReviewCopy-final.pdf

Studies in the effects of LSD-25 – http://jamanetwork.com/journals/archneurpsyc/article-abstract/652365

Acid Dreams (book) – https://books.google.com.hk/books?id=_oq8djFLFL0C&pg=PT28&lpg=PT28&dq=Werner+Stoll+Lysergic+acid&source=bl&ots=_3dVafysrk&sig=78Cx6chDin43D0FYVF1IJ20LtQ0&hl=en&sa=X&ved=0ahUKEwi21eHtyqjSAhUDKpQKHdc3Dk4Q6AEIPzAH#v=onepage&q=Werner%20Stoll%20Lysergic%20acid&f=false

Hoffman lives past 100 – http://pubs.acs.org/stoken/campaign/watchglass/pdf/10.1021/cen-v084n009.p043?hootPostID=b7cd1d2b3bcb5637c204a96b548f6cbe

LSD test on mathematics – http://www.tandfonline.com/doi/abs/10.1080/00223980.1955.9916196?journalCode=vjrl20

Possible medical uses of psychedelics
http://cen.acs.org/articles/94/i13/Psychedelic-compounds-like-ecstasy-just.html

LSD and Schizophrenia – http://journals.lww.com/jonmd/Citation/1968/08000/Lysergic_Acid_Diethylamide__Lsd_25__and.8.aspx

LSD and Alcoholism – http://ajp.psychiatryonline.org/doi/abs/10.1176/ajp.125.10.1352

LSD issues – http://ajp.psychiatryonline.org/doi/abs/10.1176/ajp.108.12.896

More LSD Issues – http://www.nejm.org/doi/full/10.1056/NEJM196512022732302

US Drug Scheduling – https://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm

St. Anthony’s fire and alchemy:
http://www.jstor.org/stable/776751?seq=6#page_scan_tab_contents

Ergotism and Salem witch trials possible connection
http://science.sciencemag.org/content/sci/192/4234/21.full.pdf
Caporeal, L.R. Ergotism: The Satan loosed in Salem? Science 1976, 192(4234), p. 21-26.

CURRENT RESEARCH IN LSD

2016: Survey of research antidepressive, anti-addictive, and anti-anxiety potentials in LSD.
http://journals.sagepub.com/doi/abs/10.1177/2045125316638008

Jan, 2017: study in Cell investigates the crystal structure of LSD and its biochemical effect on the brain.
http://www.cell.com/cell/abstract/S0092-8674(16)31749-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867416317494%3Fshowall%3Dtrue

Feb, 2017: study identifies serotonin receptor in brain respsobile for “feeling of meaning” and actually studies why LSD makes music sound.
http://www.cell.com/current-biology/abstract/S0960-9822(16)31510-X?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS096098221631510X%3Fshowall%3Dtrue

Jan, 2017: A look into LSD induced psychedelic phosphenes, and the role of biocheemiluminescence.
https://www.degruyter.com/view/j/revneuro.ahead-of-print/revneuro-2016-0047/revneuro-2016-0047.xml

Jan 2017: A look into why LSD is so difficult to find in urine tests.
https://www.degruyter.com/view/j/cclm.2017.55.issue-1/cclm-2016-0341/cclm-2016-0341.xml

2016: How LSD Affects Perception of Language
http://www.tandfonline.com/doi/full/10.1080/23273798.2016.1217030

Jan 2016: How LSD affects Circadian Rhythm.
http://www.fasebj.org/content/30/1_Supplement/930.4.short

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